About BioPQQ

Brief Introduction of PQQ

PQQ

  • Coenzyme concerning redox cycling identified in 1979
  • Water-soluble compound (reddish brown powder)

 

Distribution

  • In daily foods and beverages
  • In human tissues, organs and human milk

Safety

  • NOAEL > 100mg/kg/day (rat, 90-day, oral)
  • Core batteries of genotoxicity study: Negative
  • Human clinical study (20 and 60mg/day): No toxicity

Functions

  • Neuroprotective activity
  • Anti-oxidative activity
  • Mitochondrial biogenesis

Present situation

  • NDI(New Dietary ingredients) review accepted by FDA
    (“Life Sciences Research Office” reached positive conclusion)
  • Food-grade PQQ is supplied in US market only from MGC

Key milestone

1979Salisbury SA et al. (Nature)
& Duine JA et al.PQQ was discovered from microorganisms as a cofactor for alcohol dehydrogenases.

1987MGCStarted supplying PQQ as a reagent for research purpose

1989Killgore J et al. (Science)PQQ-deficiency symptoms in mice were discovered.

2003Kasahara T et al. (Nature)PQQ should be classified as a new B vitamin.

2008MGCNDI review accepted by FDA
Commercialized PQQ